An ingredient that has shown utility in dealing with anemia, colic pain, diarrhea, hematuria, menorrhagia, obstetric conditions, spermatorrhea, and splenomegaly. The seeds of the holarrhena plant have been known to support the body in its efforts to remedy chronic dysentery. While the leaves have been used to treat chronic bronchitis, the bark has shown to be useful in supporting the body’s ability to overcome colitis.
Studies have been conducted to establish pharmacological basis for the known traditional benefits of holarrhena. These studies indicate that the gut stimulant and relaxant activities of Holarrhena antidysenterica are mediated possibly through activation of histamine receptors and Ca(++) channel blockade, respectively and one study provides sound mechanistic background for its usefulness in gut motility disorders such as constipation, colic, and possibly diarrhea.