Detox Learning Center

Wagner S. da-Silva, Scott Ribich, Rafael Arrojo e Drigo, Melany Castillo, Mary-Elizabeth Patty, and Antonio C. Bianco

The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure. We now report that both TUDCA and 4-PBA are capable of activating the D2 pathway in a number of cell models and also when administered to mice.