Detox Learning Center

Michael H. Nathanson, Angela D. Burgstahler, Anatoly Masyuk and Nicholas F. LaRusso

Stimulation of ATP secretion in the liver by therapeutic bile acids. UDCA is rapidly conjugated to TUDCA in the liver, so the effects of both of these bile acids on isolated rat hepatocytes were examined. UDCA and TUDCA each induced isolated rat hepatocytes to release ATP, while three other bile acids had minimal or no effects